Magnificamide is a new effective mammalian a-amylase inhibitor

Vitamin D: Is There a New Era?

  Background: In recent decades, much interest has been focused on investigating new roles of vitamin D in human body beyond the mineral-ion homeostasis. Methods: By searching medical databases such as PubMed, over 16000 articles were found which have been published since 2000 on novel aspects of vitamin D in health and diseases. Results: Of great interest was the effects of vitamin D on ...

How Effective is Clinical Supervision in Nursing? A Systematic Review

Background: Clinical supervision is a process of learning and professional support for nurses in developing their practice through regular discussions with experienced and knowledgeable colleagues. However, it remains challenging to ensure the effectiveness of its implementation across healthcare organizations. This review is going to answer the question: What effect does clinical supervision h...

Mycophenolic acid is a new Nox2 inhibitor.

Organ transplantation owes its spectacular development in recent decades to the introduction of immunosuppressive drugs capable of preventing allograft rejection. However, vasculopathy remains a major cause of long-term graft failure; thus, a better understanding of its mechanisms is required to improve tolerance. Because endothelial dysfunction is an early manifestation of vascular disorders, ...

Is Medical Application Software a New Strategy for Oncologists?

A novel alpha-amylase inhibitor from amaranth (Amaranthus hypocondriacus) seeds.

The major alpha-amylase inhibitor (AAI) present in the seeds of Amaranthus hypocondriacus, a variety of the Mexican crop plant amaranth, is a 32-residue-long polypeptide with three disulfide bridges. Purified AAI strongly inhibits the alpha-amylase activity of insect larvae (Tribolium castaneum and Prostephanus truncatus) and does not inhibit proteases and mammalian alpha-amylases. AAI was sequ...